2019 updated consensus statement on the diagnosis and treatment of pediatric pulmonary hypertension: The European Pediatric Pulmonary Vascular Disease Network (EPPVDN), endorsed by AEPC, ESPR and ISHLT.

{"article_title":"2019 updated consensus statement on the diagnosis and treatment of pediatric pulmonary hypertension: The European Pediatric Pulmonary Vascular Disease Network (EPPVDN), endorsed by AEPC, ESPR and ISHLT.","author":"Hansmann G, Koestenberger M, Alastalo TP, Apitz C, Austin ED, Bonnet D, Budts W, D'Alto M, Gatzoulis MA, Hasan BS, Kozlik-Feldmann R, Kumar RK, Lammers AE, Latus H, Michel-Behnke I, Miera O, Morrell NW, Pieles G, Quandt D, Sallmon H, Schranz D, Tran-Lundmark K, Tulloh RMR, Warnecke G, W\u00e5hlander H, Weber SC, Zartner P","journal_title":"The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation","issn":"1557-3117","isbn":"","publication_date":"2019-09-01","volume":"38","issue":"9","first_page":"879","page_count":"","accession_number":"31495407","doi":"10.1016\/j.healun.2019.06.022","publisher":"Elsevier","doctype":"Consensus Development Conference","subjects":"Hypertension, Pulmonary diagnosis; Hypertension, Pulmonary therapy; Algorithms; Child; Humans","interest_area":["Cardiology"," Internal Medicine"],"abstract":"The European Pediatric Pulmonary Vascular Disease Network is a registered, non-profit organization that strives to define and develop effective, innovative diagnostic methods and treatment options in all forms of pediatric pulmonary hypertensive vascular disease, including pulmonary hypertension (PH) associated with bronchopulmonary dysplasia, PH associated with congenital heart disease (CHD), persistent PH of the newborn, and related cardiac dysfunction. The executive writing group members conducted searches of the PubMed\/MEDLINE bibliographic database (1990-2018) and held face-to-face and web-based meetings. Ten section task forces voted on the updated recommendations, based on the 2016 executive summary. Clinical trials, meta-analyses, guidelines, and other articles that include pediatric data were searched using the term \"pulmonary hypertension\" and other keywords. Class of recommendation (COR) and level of evidence (LOE) were assigned based on European Society of Cardiology\/American Heart Association definitions and on pediatric data only, or on adult studies that included >10% children or studies that enrolled adults with CHD. New definitions by the World Symposium on Pulmonary Hypertension 2018 were included. We generated 10 tables with graded recommendations (COR\/LOE). The topics include diagnosis\/monitoring, genetics\/biomarkers, cardiac catheterization, echocardiography, cardiac magnetic resonance\/chest computed tomography, associated forms of PH, intensive care unit\/lung transplantation, and treatment of pediatric PH. For the first time, a set of specific recommendations on the management of PH in middle- and low-income regions was developed. Taken together, these executive, up-to-date guidelines provide a specific, comprehensive, detailed but practical framework for the optimal clinical care of children and young adults with PH. Copyright \u00a9 2019. Published by Elsevier Inc.","url":"https:\/\/search.ebscohost.com\/login.aspx?direct=true&db=mdl&AN=31495407","isPdfLink":false,"isSAML":false,"an":"31495407","number_other":"","type_pub":"","issn_electronic":"1557-3117","languages":"English","language":"eng","date_entry":"Date Created: 20190910 Date Completed: 20201210 Latest Revision: 20220310","date_update":"20240105","titleSource":"The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation [J Heart Lung Transplant] 2019 Sep; Vol. 38 (9), pp. 879-901. Date of Electronic Publication: 2019 Jun 21.","date_pub_cy":"","type_document":"","contract_publisher":"","authored_on":"2019-09-01","description":"The European Pediatric Pulmonary Vascular Disease Network is a registered, non-profit organization that strives to define and develop effective, innovative diagnostic methods and treatment options in all forms of pediatric pulmonary hypertensive vascular disease, including pulmonary hypertension (PH) associated with bronchopulmonary dysplasia, PH associated with congenital heart disease (CHD), persistent PH of the newborn, and related cardiac dysfunction. The executive writing group members conducted searches of the PubMed\/MEDLINE bibliographic database (1990-2018) and held face-to-face and web-based meetings. Ten section task forces voted on the updated recommendations, based on the 2016 executive summary. Clinical trials, meta-analyses, guidelines, and other articles that include pediatric data were searched using the term "pulmonary hypertension" and other keywords. Class of recommendation (COR) and level of evidence (LOE) were assigned based on European Society of Cardiology\/American Heart Association definitions and on pediatric data only, or on adult studies that included >10% children or studies that enrolled adults with CHD. New definitions by the World Symposium on Pulmonary Hypertension 2018 were included. We generated 10 tables with graded recommendations (COR\/LOE). The topics include diagnosis\/monitoring, genetics\/biomarkers, cardiac catheterization, echocardiography, cardiac magnetic resonance\/chest computed tomography, associated forms of PH, intensive care unit\/lung transplantation, and treatment of pediatric PH. For the first time, a set of specific recommendations on the management of PH in middle- and low-income regions was developed. Taken together, these executive, up-to-date guidelines provide a specific, comprehensive, detailed but practical framework for the optimal clinical care of children and young adults with PH.<br \/> (Copyright © 2019. Published by Elsevier Inc.)","upload_link":"https:\/\/search.ebscohost.com\/login.aspx?direct=true&site=eds-live&scope=site&db=mdl&AN=31495407&authtype=shib&custid=ns346513&group=main&profile=eds","no_of_pages":"","authored_by":"Hansmann G, Koestenberger M, Alastalo TP, Apitz C, Austin ED, Bonnet D, Budts W, D'Alto M, Gatzoulis MA, Hasan BS, Kozlik-Feldmann R, Kumar RK, Lammers AE, Latus H, Michel-Behnke I, Miera O, Morrell NW, Pieles G, Quandt D, Sallmon H, Schranz D, Tran-Lundmark K, Tulloh RMR, Warnecke G, W\u00e5hlander H, Weber SC, Zartner P"}