Therapy for Pulmonary Arterial Hypertension in Adults: Update of the CHEST Guideline and Expert Panel Report.

{"article_title":"Therapy for Pulmonary Arterial Hypertension in Adults: Update of the CHEST Guideline and Expert Panel Report.","author":"Klinger JR, Elliott CG, Levine DJ, Bossone E, Duvall L, Fagan K, Frantsve-Hawley J, Kawut SM, Ryan JJ, Rosenzweig EB, Sederstrom N, Steen VD, Badesch DB","journal_title":"Chest","issn":"1931-3543","isbn":"","publication_date":"2019-03-01","volume":"155","issue":"3","first_page":"565","page_count":"","accession_number":"30660783","doi":"10.1016\/j.chest.2018.11.030","publisher":"Elsevier","doctype":"Journal Article","subjects":"Antihypertensive Agents classification; Antihypertensive Agents pharmacology; Pulmonary Arterial Hypertension drug therapy; Respiratory System Agents classification; Respiratory System Agents pharmacology; Adult; Diagnostic Techniques, Respiratory System; Drug Monitoring methods; Evidence-Based Medicine; Exercise Tolerance drug effects; Humans; Pulmonary Arterial Hypertension diagnosis; Pulmonary Arterial Hypertension etiology; Pulmonary Medicine methods; Pulmonary Medicine standards","interest_area":["Pulmonology"],"abstract":"Background: Pulmonary arterial hypertension (PAH) carries a poor prognosis if not promptly diagnosed and appropriately treated. The development and approval of 14 medications over the last several decades have led to a rapidly evolving approach to therapy, and have necessitated periodic updating of evidence-based treatment guidelines. This guideline statement, which now includes a visual algorithm to enhance its clinical utility, represents the fourth iteration of the American College of Chest Physicians Guideline and Expert Panel Report on Pharmacotherapy for PAH. Methods: The guideline panel conducted an updated systematic review to identify studies published after those included in the 2014 guideline. A systematic literature search was conducted using MEDLINE via PubMed and the Cochrane Library. The quality of the body of evidence was assessed for each critical or important outcome of interest using the Grading of Recommendations Assessment, Development and Evaluation approach. Graded recommendations and ungraded consensus-based statements were developed and voted on using a modified Delphi technique to achieve consensus. Results: Two new recommendations on combination therapy and two ungraded consensus-based statements on palliative care were developed. An evidence-based and consensus-driven treatment algorithm was created to guide the clinician through an organized approach to management, and to direct readers to the appropriate area of the document for more detailed information. Conclusions: Therapeutic options for the patient with PAH continue to expand through basic discovery, translational science, and clinical trials. Optimal use of new treatment options requires prompt evaluation at an expert center, utilization of current evidence-based guidelines, and collaborative care using sound clinical judgment. Copyright \u00a9 2019 American College of Chest Physicians. Published by Elsevier Inc. All rights reserved.","url":"https:\/\/search.ebscohost.com\/login.aspx?direct=true&db=mdl&AN=30660783","isPdfLink":false,"isSAML":false,"an":"30660783","number_other":"","type_pub":"","issn_electronic":"1931-3543","languages":"English","language":"eng","date_entry":"Date Created: 20190121 Date Completed: 20191220 Latest Revision: 20210110","date_update":"20240105","titleSource":"Chest [Chest] 2019 Mar; Vol. 155 (3), pp. 565-586. Date of Electronic Publication: 2019 Jan 17.","date_pub_cy":"","type_document":"","contract_publisher":"","authored_on":"2019-03-01","description":"Background: Pulmonary arterial hypertension (PAH) carries a poor prognosis if not promptly diagnosed and appropriately treated. The development and approval of 14 medications over the last several decades have led to a rapidly evolving approach to therapy, and have necessitated periodic updating of evidence-based treatment guidelines. This guideline statement, which now includes a visual algorithm to enhance its clinical utility, represents the fourth iteration of the American College of Chest Physicians Guideline and Expert Panel Report on Pharmacotherapy for PAH.<br \/>Methods: The guideline panel conducted an updated systematic review to identify studies published after those included in the 2014 guideline. A systematic literature search was conducted using MEDLINE via PubMed and the Cochrane Library. The quality of the body of evidence was assessed for each critical or important outcome of interest using the Grading of Recommendations Assessment, Development and Evaluation approach. Graded recommendations and ungraded consensus-based statements were developed and voted on using a modified Delphi technique to achieve consensus.<br \/>Results: Two new recommendations on combination therapy and two ungraded consensus-based statements on palliative care were developed. An evidence-based and consensus-driven treatment algorithm was created to guide the clinician through an organized approach to management, and to direct readers to the appropriate area of the document for more detailed information.<br \/>Conclusions: Therapeutic options for the patient with PAH continue to expand through basic discovery, translational science, and clinical trials. Optimal use of new treatment options requires prompt evaluation at an expert center, utilization of current evidence-based guidelines, and collaborative care using sound clinical judgment.<br \/> (Copyright © 2019 American College of Chest Physicians. Published by Elsevier Inc. All rights reserved.)","upload_link":"https:\/\/search.ebscohost.com\/login.aspx?direct=true&site=eds-live&scope=site&db=mdl&AN=30660783&authtype=shib&custid=ns346513&group=main&profile=eds","no_of_pages":"","authored_by":"Klinger JR, Elliott CG, Levine DJ, Bossone E, Duvall L, Fagan K, Frantsve-Hawley J, Kawut SM, Ryan JJ, Rosenzweig EB, Sederstrom N, Steen VD, Badesch DB"}