Measurement of axonal excitability: Consensus guidelines.

{"article_title":"Measurement of axonal excitability: Consensus guidelines.","author":"Kiernan MC, Bostock H, Park SB, Kaji R, Krarup C, Krishnan AV, Kuwabara S, Lin CS, Misawa S, Moldovan M, Sung J, Vucic S, Wainger BJ, Waxman S, Burke D","journal_title":"Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology","issn":"1872-8952","isbn":"","publication_date":"2020-01-01","volume":"131","issue":"1","first_page":"308","page_count":"","accession_number":"31471200","doi":"10.1016\/j.clinph.2019.07.023","publisher":"Elsevier","doctype":"Journal Article","subjects":"Axons physiology; Consensus; Nervous System Diseases physiopathology; Action Potentials; Electric Stimulation instrumentation; Electrodes, Implanted; Equipment Design; Humans; Ion Channels physiology; Membrane Potentials physiology; Models, Neurological; Neurophysiology instrumentation; Neurophysiology methods; Sensory Thresholds physiology; Software","interest_area":["Neurology"],"abstract":"Measurement of axonal excitability provides an in vivo indication of the properties of the nerve membrane and of the ion channels expressed on these axons. Axonal excitability techniques have been utilised to investigate the pathophysiological mechanisms underlying neurological diseases. This document presents guidelines derived for such studies, based on a consensus of international experts, and highlights the potential difficulties when interpreting abnormalities in diseased axons. The present manuscript provides a state-of-the-art review of the findings of axonal excitability studies and their interpretation, in addition to suggesting guidelines for the optimal performance of excitability studies. Copyright \u00a9 2019 International Federation of Clinical Neurophysiology. Published by Elsevier B.V. All rights reserved.","url":"https:\/\/search.ebscohost.com\/login.aspx?direct=true&db=mdl&AN=31471200","isPdfLink":false,"isSAML":false,"an":"31471200","number_other":"","type_pub":"","issn_electronic":"1872-8952","languages":"English","language":"eng","date_entry":"Date Created: 20190901 Date Completed: 20200706 Latest Revision: 20200706","date_update":"20240104","titleSource":"Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology [Clin Neurophysiol] 2020 Jan; Vol. 131 (1), pp. 308-323. Date of Electronic Publication: 2019 Aug 02.","date_pub_cy":"","type_document":"","contract_publisher":"","authored_on":"2020-01-01","description":"Measurement of axonal excitability provides an in vivo indication of the properties of the nerve membrane and of the ion channels expressed on these axons. Axonal excitability techniques have been utilised to investigate the pathophysiological mechanisms underlying neurological diseases. This document presents guidelines derived for such studies, based on a consensus of international experts, and highlights the potential difficulties when interpreting abnormalities in diseased axons. The present manuscript provides a state-of-the-art review of the findings of axonal excitability studies and their interpretation, in addition to suggesting guidelines for the optimal performance of excitability studies.<br \/> (Copyright © 2019 International Federation of Clinical Neurophysiology. Published by Elsevier B.V. All rights reserved.)","upload_link":"https:\/\/search.ebscohost.com\/login.aspx?direct=true&site=eds-live&scope=site&db=mdl&AN=31471200&authtype=shib&custid=ns346513&group=main&profile=eds","no_of_pages":"","authored_by":"Kiernan MC, Bostock H, Park SB, Kaji R, Krarup C, Krishnan AV, Kuwabara S, Lin CS, Misawa S, Moldovan M, Sung J, Vucic S, Wainger BJ, Waxman S, Burke D"}