Guidelines for non-transplant chemotherapy for treatment of systemic AL amyloidosis: EHA-ISA working group.

{"article_title":"Guidelines for non-transplant chemotherapy for treatment of systemic AL amyloidosis: EHA-ISA working group.","author":"Wechalekar AD, Cibeira MT, Gibbs SD, Jaccard A, Kumar S, Merlini G, Palladini G, Sanchorawala V, Sch\u00f6nland S, Venner C, Boccadoro M, Kastritis E","journal_title":"Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis","issn":"1744-2818","isbn":"","publication_date":"2023-03-01","volume":"30","issue":"1","first_page":"3","page_count":"","accession_number":"35838162","doi":"10.1080\/13506129.2022.2093635","publisher":"Taylor & Francis","doctype":"Guideline","subjects":"Amyloidosis drug therapy; Drug-Related Side Effects and Adverse Reactions; Immunoglobulin Light-chain Amyloidosis drug therapy; Humans; Amyloid; Neoplasm Recurrence, Local","interest_area":["Oncology"," Allergy Immunology & Inflammation"],"abstract":"Background: This guideline has been developed jointly by the European Society of Haematology and International Society of Amyloidosis recommending non-transplant chemotherapy treatment for patients with AL amyloidosis. Methods: A review of literature and grading of evidence as well as expert recommendations by the ESH and ISA guideline committees. Results and Conclusions: The recommendations of this committee suggest that treatment follows the clinical presentation which determines treatment tolerance tempered by potential side effects to select and modify use of drugs in AL amyloidosis. All patients with AL amyloidosis should be considered for clinical trials where available. Daratumumab-VCD is recommended from most untreated patients (VCD or VMDex if daratumumab is unavailable). At relapse, the two guiding principles are the depth and duration of initial response, use of a class of agents not previously exposed as well as the limitation imposed by patients' fitness\/frailty and end organ damage. Targeted agents like venetoclax need urgent prospective evaluation. Future prospective trials should include advanced stage patients to allow for evidence-based treatment decisions. Therapies targeting amyloid fibrils or those reducing the proteotoxicity of amyloidogenic light chains\/oligomers are urgently needed.","url":"https:\/\/search.ebscohost.com\/login.aspx?direct=true&db=mdl&AN=35838162","isPdfLink":true,"isSAML":false,"an":"35838162","number_other":"","type_pub":"","issn_electronic":"1744-2818","languages":"English","language":"eng","date_entry":"Date Created: 20220715 Date Completed: 20230315 Latest Revision: 20230315","date_update":"20240104","titleSource":"Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis [Amyloid] 2023 Mar; Vol. 30 (1), pp. 3-17. Date of Electronic Publication: 2022 Jul 15.","date_pub_cy":"","type_document":"","contract_publisher":"","authored_on":"2023-03-01","description":"Background: This guideline has been developed jointly by the European Society of Haematology and International Society of Amyloidosis recommending non-transplant chemotherapy treatment for patients with AL amyloidosis.<br \/>Methods: A review of literature and grading of evidence as well as expert recommendations by the ESH and ISA guideline committees.<br \/>Results and Conclusions: The recommendations of this committee suggest that treatment follows the clinical presentation which determines treatment tolerance tempered by potential side effects to select and modify use of drugs in AL amyloidosis. All patients with AL amyloidosis should be considered for clinical trials where available. Daratumumab-VCD is recommended from most untreated patients (VCD or VMDex if daratumumab is unavailable). At relapse, the two guiding principles are the depth and duration of initial response, use of a class of agents not previously exposed as well as the limitation imposed by patients' fitness\/frailty and end organ damage. Targeted agents like venetoclax need urgent prospective evaluation. Future prospective trials should include advanced stage patients to allow for evidence-based treatment decisions. Therapies targeting amyloid fibrils or those reducing the proteotoxicity of amyloidogenic light chains\/oligomers are urgently needed.","upload_link":"https:\/\/search.ebscohost.com\/login.aspx?direct=true&site=eds-live&db=mdl&AN=35838162&authtype=shib&custid=ns346513&group=main&profile=eds","no_of_pages":"","authored_by":"Wechalekar AD, Cibeira MT, Gibbs SD, Jaccard A, Kumar S, Merlini G, Palladini G, Sanchorawala V, Sch\u00f6nland S, Venner C, Boccadoro M, Kastritis E","additionalInfo":{"Authored_By":"Wechalekar AD, Cibeira MT, Gibbs SD, Jaccard A, Kumar S, Merlini G, Palladini G, Sanchorawala V, Sch\u00f6nland S, Venner C, Boccadoro M, Kastritis E","Journal_Info":"Publisher: Taylor & Francis Country of Publication: England NLM ID: 9433802 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1744-2818 (Electronic) Linking ISSN: 13506129 NLM ISO Abbreviation: Amyloid Subsets: MEDLINE","Publication_Type":"Guideline; Journal Article; Review","Published_Date":"2023-03-01","Source":"Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis [Amyloid] 2023 Mar; Vol. 30 (1), pp. 3-17. Date of Electronic Publication: 2022 Jul 15.","Languages":"English","Electronic_ISSN":"1744-2818","MeSH_Terms":"Amyloidosis*\/drug therapy , Drug-Related Side Effects and Adverse Reactions* , Immunoglobulin Light-chain Amyloidosis*\/drug therapy, Humans ; Amyloid ; Neoplasm Recurrence, Local","Subjects":"Humans, Amyloid, Neoplasm Recurrence, Local, Amyloidosis drug therapy, Drug-Related Side Effects and Adverse Reactions, Immunoglobulin Light-chain Amyloidosis drug therapy","Title_Abbreviations":"Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis","Volume":"30"},"header":{"DbId":"mdl","DbLabel":"MEDLINE Ultimate","An":"35838162","RelevancyScore":"957","PubType":"Academic Journal","PubTypeId":"academicJournal","PreciseRelevancyScore":"957.368286132813"},"plink":"https:\/\/search.ebscohost.com\/login.aspx?direct=true&site=eds-live&db=mdl&AN=35838162&authtype=shib&custid=ns346513&group=main&profile=eds"}