Congress of Neurological Surgeons Systematic Review and Evidence-Based Guidelines for Pediatric Myelomeningocele: Executive Summary.

{"article_title":"Congress of Neurological Surgeons Systematic Review and Evidence-Based Guidelines for Pediatric Myelomeningocele: Executive Summary.","author":"Mazzola CA, Assassi N, Baird LC, Bauer DF, Beier AD, Blount JP, Durham SR, Flannery AM, Klimo P, McClung-Smith C, Nikas DC, Rehring P, Tamber MS, Tyagi R","journal_title":"Neurosurgery","issn":"1524-4040","isbn":"","publication_date":"2019-09-01","volume":"85","issue":"3","first_page":"299","page_count":"","accession_number":"31418038","doi":"10.1093\/neuros\/nyz261","publisher":"Lippincott Williams & Wilkins, Inc","doctype":"Journal Article","subjects":"United States; Meningomyelocele; Child; Female; Humans; Infant; Pregnancy; United States","interest_area":["Pediatric Medicine"," Neurology"," Surgery"],"abstract":"Background: The incidence of spina bifida (SB) in the developing world is higher than in the United States because of malnutrition and folic acid deficiency during pregnancy. Advances in technology have made prenatal repair of myelomeningocele (MM) possible. Objective: The objective of the guidelines are, (1) To create clinical recommendations for best practices, based on a systematic review and analysis of available literature, (2) to obtain multi-disciplinary endorsement of these guidelines from relevant organizations, and (3) to disseminate the educational content to physicians to improve the care of infants with MM. Methods: The Guidelines Task Force developed search terms and strategies used to search PubMed and Embase for literature published between 1966 and September 2016. Strict inclusion\/exclusion criteria were used to screen abstracts and to develop a list of relevant articles for full-text review. Results: Guidelines authors aimed to systematically review the literature and make evidence based recommendations about the timing of closure after birth, hydrocephalus, the impact of prenatal closure, and the effect of prenatal closure on ambulation ability and tethered spinal cord. Evidence concerning persistent ventriculomegaly and cognitive impairment was also evaluated. Hundreds of abstracts were identified and reviewed for each of the 5 topics. A total of 14 studies met stringent inclusion criteria. Conclusion: Based on a comprehensive systematic review, a total of 5 clinical practice recommendations were developed, with 1 Level I, 2 Level II and 2 Level III recommendations.The full guideline can be found at https:\/\/www.cns.org\/guidelines\/guidelines-spina-bifida-chapter-1. Copyright \u00a9 2019 by the Congress of Neurological Surgeons.","url":"https:\/\/search.ebscohost.com\/login.aspx?direct=true&db=mdl&AN=31418038","isPdfLink":false,"isSAML":false,"an":"31418038","number_other":"","type_pub":"","issn_electronic":"1524-4040","languages":"English","language":"eng","date_entry":"Date Created: 20190817 Date Completed: 20200325 Latest Revision: 20200325","date_update":"20240105","titleSource":"Neurosurgery [Neurosurgery] 2019 Sep 01; Vol. 85 (3), pp. 299-301.","date_pub_cy":"","type_document":"","contract_publisher":"","authored_on":"2019-09-01","description":"Background: The incidence of spina bifida (SB) in the developing world is higher than in the United States because of malnutrition and folic acid deficiency during pregnancy. Advances in technology have made prenatal repair of myelomeningocele (MM) possible.<br \/>Objective: The objective of the guidelines are, (1) To create clinical recommendations for best practices, based on a systematic review and analysis of available literature, (2) to obtain multi-disciplinary endorsement of these guidelines from relevant organizations, and (3) to disseminate the educational content to physicians to improve the care of infants with MM.<br \/>Methods: The Guidelines Task Force developed search terms and strategies used to search PubMed and Embase for literature published between 1966 and September 2016. Strict inclusion\/exclusion criteria were used to screen abstracts and to develop a list of relevant articles for full-text review.<br \/>Results: Guidelines authors aimed to systematically review the literature and make evidence based recommendations about the timing of closure after birth, hydrocephalus, the impact of prenatal closure, and the effect of prenatal closure on ambulation ability and tethered spinal cord. Evidence concerning persistent ventriculomegaly and cognitive impairment was also evaluated. Hundreds of abstracts were identified and reviewed for each of the 5 topics. A total of 14 studies met stringent inclusion criteria.<br \/>Conclusion: Based on a comprehensive systematic review, a total of 5 clinical practice recommendations were developed, with 1 Level I, 2 Level II and 2 Level III recommendations.The full guideline can be found at https:\/\/www.cns.org\/guidelines\/guidelines-spina-bifida-chapter-1.<br \/> (Copyright © 2019 by the Congress of Neurological Surgeons.)","upload_link":"https:\/\/search.ebscohost.com\/login.aspx?direct=true&site=eds-live&scope=site&db=mdl&AN=31418038&authtype=shib&custid=ns346513&group=main&profile=eds","no_of_pages":"","authored_by":"Mazzola CA, Assassi N, Baird LC, Bauer DF, Beier AD, Blount JP, Durham SR, Flannery AM, Klimo P, McClung-Smith C, Nikas DC, Rehring P, Tamber MS, Tyagi R"}