Hormesis and medicine.

{"article_title":"Conformal radiotherapy in management of soft tissue sarcoma in adults.","author":"Le P\u00e9choux C, Llacer C, Sargos P, Moureau-Zabotto L, Ducassou A, Sunyach MP, Biston MC, Thariat J","journal_title":"Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique","issn":"1769-6658","isbn":"","publication_date":"2022-02-01","volume":"26","issue":"1-Feb","first_page":"377","page_count":"","accession_number":"34961656","doi":"10.1016\/j.canrad.2021.11.023","publisher":"Elsevier","doctype":"Journal Article","subjects":"France; Radiotherapy, Conformal methods; Sarcoma radiotherapy; Soft Tissue Neoplasms radiotherapy; Adult; Brachytherapy methods; Clinical Decision-Making; Extremities; Female; France; Humans; Neoplasm Staging classification; Organs at Risk; Radiation Oncology; Radiosurgery; Radiotherapy, Adjuvant; Rare Diseases radiotherapy; Retroperitoneal Neoplasms radiotherapy; Retroperitoneal Neoplasms surgery; Sarcoma pathology; Sarcoma surgery; Soft Tissue Neoplasms pathology; Soft Tissue Neoplasms surgery; Torso; Tumor Burden; Uterine Neoplasms radiotherapy; Uterine Neoplasms surgery","interest_area":["Oncology"," Orthopedic"],"abstract":"We present the update of the recommendations of the French society of radiation oncology on soft tissue sarcomas. Currently, the initial management of sarcomas is very important as it may impact on patients' quality of life, especially in limb soft tissue sarcomas, and on overall survival in trunk sarcomas. Radiotherapy has to be discussed within a multidisciplinary board meeting with results of biopsy, eventually reexamined by a dedicated sarcoma pathologist. The role of radiotherapy varies according to localization of soft tissue sarcoma. It is part of the standard treatment in grade 2 and 3 sarcomas of the extremities and superficial trunk>5cm. In case of R1 or R2 resection, reexcision should be discussed. In such cases, it may be delivered preoperatively (50Gy\/25 fractions of 2Gy) or postoperatively. In retroperitoneal sarcomas, preoperative conformal radiotherapy with or without modulated intensity cannot be proposed systematically in daily practice. Concomitant chemoradiotherapy cannot be considered a standard treatment. Intensity-modulated radiotherapy has become widely available. Other soft tissue sarcoma sites such as trunk, head and neck and gynaecological soft tissue sarcomas will be addressed, as well as other techniques that may be used such as brachytherapy and proton therapy. Copyright \u00a9 2021 Soci\u00e9t\u00e9 fran\u00e7aise de radioth\u00e9rapie oncologique (SFRO). Published by Elsevier Masson SAS. All rights reserved.","url":"https:\/\/search.ebscohost.com\/login.aspx?direct=true&db=mdl&AN=34961656","isPdfLink":true,"isSAML":false,"an":"34961656","number_other":"","type_pub":"","issn_electronic":"1769-6658","languages":"English","language":"eng","date_entry":"Date Created: 20211228 Date Completed: 20220217 Latest Revision: 20220217","date_update":"20240104","titleSource":"Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique [Cancer Radiother] 2022 Feb-Apr; Vol. 26 (1-2), pp. 377-387. Date of Electronic Publication: 2021 Dec 24.","date_pub_cy":"","type_document":"","contract_publisher":"","authored_on":"2022-02-01","description":"We present the update of the recommendations of the French society of radiation oncology on soft tissue sarcomas. Currently, the initial management of sarcomas is very important as it may impact on patients' quality of life, especially in limb soft tissue sarcomas, and on overall survival in trunk sarcomas. Radiotherapy has to be discussed within a multidisciplinary board meeting with results of biopsy, eventually reexamined by a dedicated sarcoma pathologist. The role of radiotherapy varies according to localization of soft tissue sarcoma. It is part of the standard treatment in grade 2 and 3 sarcomas of the extremities and superficial trunk>5cm. In case of R1 or R2 resection, reexcision should be discussed. In such cases, it may be delivered preoperatively (50Gy\/25 fractions of 2Gy) or postoperatively. In retroperitoneal sarcomas, preoperative conformal radiotherapy with or without modulated intensity cannot be proposed systematically in daily practice. Concomitant chemoradiotherapy cannot be considered a standard treatment. Intensity-modulated radiotherapy has become widely available. Other soft tissue sarcoma sites such as trunk, head and neck and gynaecological soft tissue sarcomas will be addressed, as well as other techniques that may be used such as brachytherapy and proton therapy.<br \/> (Copyright © 2021 Société française de radiothérapie oncologique (SFRO). Published by Elsevier Masson SAS. All rights reserved.)","upload_link":"https:\/\/search.ebscohost.com\/login.aspx?direct=true&site=eds-live&db=edb&AN=34961656&authtype=shib&custid=ns346513&group=main&profile=eds","no_of_pages":"","authored_by":"Le P\u00e9choux C, Llacer C, Sargos P, Moureau-Zabotto L, Ducassou A, Sunyach MP, Biston MC, Thariat J","additionalInfo":{"Authored_By":"Calabrese, Edward J.","Published_Date":"2008-11-01","Source":"British Journal of Clinical Pharmacology; Nov2008, Vol. 66 Issue 5, p594-617, 24p, 1 Diagram, 13 Graphs","Languages":"English","Subjects":"HORMESIS, CLINICAL medicine, ANXIETY, CEREBROVASCULAR disease, CANCER chemotherapy, DERMATOLOGY, OSTEOPOROSIS, RETINAL diseases","Title_Abbreviations":"British Journal of Clinical Pharmacology","Volume":"66"},"header":{"DbId":"edb","DbLabel":"Complementary Index","An":"34961656","RelevancyScore":"833","PubType":"Academic Journal","PubTypeId":"academicJournal","PreciseRelevancyScore":"833.212341308594"},"plink":"https:\/\/search.ebscohost.com\/login.aspx?direct=true&site=eds-live&db=edb&AN=34961656&authtype=shib&custid=ns346513&group=main&profile=eds"}