An accurate knowledge of the epidemiology of community-acquired pneumonia (CAP) is key for selecting appropriate antimicrobial treatments. Very few etiological studies assessed the appropriateness of empiric guideline recommendations at a multinational level. This study aims at the following: (i) describing the bacterial etiologic distribution of CAP and (ii) assessing the appropriateness of the empirical treatment recommendations by clinical practice guidelines (CPGs) for CAP in light of the bacterial pathogens diagnosed as causative agents of CAP. Secondary analysis of the GLIMP, a point-prevalence international study which enrolled adults hospitalized with CAP in 2015. The analysis was limited to immunocompetent patients tested for bacterial CAP agents within 24 h of admission. The CAP CPGs evaluated included the following: the 2007 and 2019 American Thoracic Society/Infectious Diseases Society of America (ATS/IDSA), the European Respiratory Society (ERS), and selected country-specific CPGs. Among 2564 patients enrolled, 35.3% had an identifiable pathogen. Streptococcus pneumoniae (8.2%) was the most frequently identified pathogen, followed by Pseudomonas aeruginosa (4.1%) and Klebsiella pneumoniae (3.4%). CPGs appropriately recommend covering more than 90% of all the potential pathogens causing CAP, with the exception of patients enrolled from Germany, Pakistan, and Croatia. The 2019 ATS/IDSA CPGs appropriately recommend covering 93.6% of the cases compared with 90.3% of the ERS CPGs (p < 0.01). S. pneumoniae remains the most common pathogen in patients hospitalized with CAP. Multinational CPG recommendations for patients with CAP seem to appropriately cover the most common pathogens and should be strongly encouraged for the management of CAP patients.
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{"article_title":"Bacterial etiology of community-acquired pneumonia in immunocompetent hospitalized patients and appropriateness of empirical treatment recommendations: an international point-prevalence study.","author":"Carugati M, Aliberti S, Sotgiu G, Blasi F, Gori A, Menendez R, Encheva M, Gallego M, Leuschner P, Ruiz-Buitrago S, Battaglia S, Fantini R, Pascual-Guardia S, Marin-Corral J, Restrepo MI","journal_title":"European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology","issn":"1435-4373","isbn":"","publication_date":"2020-08-01","volume":"39","issue":"8","first_page":"1513","page_count":"","accession_number":"32242314","doi":"","publisher":"Springer","doctype":"Journal Article","subjects":"Community-Acquired Infections epidemiology; Guideline Adherence; Pneumonia, Bacterial epidemiology; Practice Guidelines as Topic; Practice Patterns, Physicians'; Pseudomonas aeruginosa; Streptococcus pneumoniae; Aged; Aged, 80 and over; Anti-Bacterial Agents therapeutic use; Community-Acquired Infections drug therapy; Community-Acquired Infections microbiology; Female; Global Health; Hospitalization; Humans; Immunocompromised Host; Male; Middle Aged; Pneumonia, Bacterial drug therapy; Pneumonia, Bacterial microbiology; Prevalence","interest_area":["Pulmonology"," Emergency Medicine"],"abstract":"An accurate knowledge of the epidemiology of community-acquired pneumonia (CAP) is key for selecting appropriate antimicrobial treatments. Very few etiological studies assessed the appropriateness of empiric guideline recommendations at a multinational level. This study aims at the following: (i) describing the bacterial etiologic distribution of CAP and (ii) assessing the appropriateness of the empirical treatment recommendations by clinical practice guidelines (CPGs) for CAP in light of the bacterial pathogens diagnosed as causative agents of CAP. Secondary analysis of the GLIMP, a point-prevalence international study which enrolled adults hospitalized with CAP in 2015. The analysis was limited to immunocompetent patients tested for bacterial CAP agents within 24 h of admission. The CAP CPGs evaluated included the following: the 2007 and 2019 American Thoracic Society\/Infectious Diseases Society of America (ATS\/IDSA), the European Respiratory Society (ERS), and selected country-specific CPGs. Among 2564 patients enrolled, 35.3% had an identifiable pathogen. Streptococcus pneumoniae (8.2%) was the most frequently identified pathogen, followed by Pseudomonas aeruginosa (4.1%) and Klebsiella pneumoniae (3.4%). CPGs appropriately recommend covering more than 90% of all the potential pathogens causing CAP, with the exception of patients enrolled from Germany, Pakistan, and Croatia. The 2019 ATS\/IDSA CPGs appropriately recommend covering 93.6% of the cases compared with 90.3% of the ERS CPGs (p < 0.01). S. pneumoniae remains the most common pathogen in patients hospitalized with CAP. Multinational CPG recommendations for patients with CAP seem to appropriately cover the most common pathogens and should be strongly encouraged for the management of CAP patients.","url":"https:\/\/search.ebscohost.com\/login.aspx?direct=true&db=mdl&AN=32242314","isPdfLink":true,"isSAML":false,"an":"32242314","number_other":"","type_pub":"","issn_electronic":"1435-4373","languages":"English","language":"eng","date_entry":"","date_update":"","titleSource":"European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology [Eur J Clin Microbiol Infect Dis] 2020 Aug; Vol. 39 (8), pp. 1513-1525. Date of Electronic Publication: 2020 Apr 03.","date_pub_cy":"","type_document":"","contract_publisher":"","authored_on":"2020-08-01","description":"An accurate knowledge of the epidemiology of community-acquired pneumonia (CAP) is key for selecting appropriate antimicrobial treatments. Very few etiological studies assessed the appropriateness of empiric guideline recommendations at a multinational level. This study aims at the following: (i) describing the bacterial etiologic distribution of CAP and (ii) assessing the appropriateness of the empirical treatment recommendations by clinical practice guidelines (CPGs) for CAP in light of the bacterial pathogens diagnosed as causative agents of CAP. Secondary analysis of the GLIMP, a point-prevalence international study which enrolled adults hospitalized with CAP in 2015. The analysis was limited to immunocompetent patients tested for bacterial CAP agents within 24 h of admission. The CAP CPGs evaluated included the following: the 2007 and 2019 American Thoracic Society\/Infectious Diseases Society of America (ATS\/IDSA), the European Respiratory Society (ERS), and selected country-specific CPGs. Among 2564 patients enrolled, 35.3% had an identifiable pathogen. Streptococcus pneumoniae (8.2%) was the most frequently identified pathogen, followed by Pseudomonas aeruginosa (4.1%) and Klebsiella pneumoniae (3.4%). CPGs appropriately recommend covering more than 90% of all the potential pathogens causing CAP, with the exception of patients enrolled from Germany, Pakistan, and Croatia. The 2019 ATS\/IDSA CPGs appropriately recommend covering 93.6% of the cases compared with 90.3% of the ERS CPGs (p\u2009<\u20090.01). S. pneumoniae remains the most common pathogen in patients hospitalized with CAP. Multinational CPG recommendations for patients with CAP seem to appropriately cover the most common pathogens and should be strongly encouraged for the management of CAP patients.","upload_link":"https:\/\/search.ebscohost.com\/login.aspx?direct=true&site=eds-live&db=mdl&AN=32242314&authtype=shib&custid=ns346513&group=main&profile=eds","no_of_pages":"","authored_by":"Carugati M, Aliberti S, Sotgiu G, Blasi F, Gori A, Menendez R, Encheva M, Gallego M, Leuschner P, Ruiz-Buitrago S, Battaglia S, Fantini R, Pascual-Guardia S, Marin-Corral J, Restrepo MI","header":{"DbId":"mdl","DbLabel":"MEDLINE Ultimate","An":"32242314","RelevancyScore":"872","PubType":"Academic Journal","PubTypeId":"academicJournal","PreciseRelevancyScore":"872.4453125"},"plink":"https:\/\/search.ebscohost.com\/login.aspx?direct=true&site=eds-live&db=mdl&AN=32242314&authtype=shib&custid=ns346513&group=main&profile=eds","physicalDescription":{"Pagination":{"StartPage":"1513"}},"additionalInfo":{"Authored_By":"Carugati M, Aliberti S, Sotgiu G, Blasi F, Gori A, Menendez R, Encheva M, Gallego M, Leuschner P, Ruiz-Buitrago S, Battaglia S, Fantini R, Pascual-Guardia S, Marin-Corral J, Restrepo MI","Corporate_Authors":"GLIMP Collaborators","Journal_Info":"Publisher: Springer Country of Publication: Germany NLM ID: 8804297 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1435-4373 (Electronic) Linking ISSN: 09349723 NLM ISO Abbreviation: Eur J Clin Microbiol Infect Dis Subsets: MEDLINE","Publication_Type":"Journal Article; Multicenter Study; Practice Guideline","Published_Date":"2020-08-01","Source":"European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology [Eur J Clin Microbiol Infect Dis] 2020 Aug; Vol. 39 (8), pp. 1513-1525. Date of Electronic Publication: 2020 Apr 03.","Languages":"English","Electronic_ISSN":"1435-4373","MeSH_Terms":"Guideline Adherence* , Practice Guidelines as Topic* , Practice Patterns, Physicians'* , Pseudomonas aeruginosa* , Streptococcus pneumoniae*, Community-Acquired Infections\/*epidemiology , Pneumonia, Bacterial\/*epidemiology, Aged ; Aged, 80 and over ; Anti-Bacterial Agents\/therapeutic use ; Community-Acquired Infections\/drug therapy ; Community-Acquired Infections\/microbiology ; Female ; Global Health ; Hospitalization ; Humans ; Immunocompromised Host ; Male ; Middle Aged ; Pneumonia, Bacterial\/drug therapy ; Pneumonia, Bacterial\/microbiology ; Prevalence","Subjects":"Aged, Aged, 80 and over, Anti-Bacterial Agents therapeutic use, Community-Acquired Infections drug therapy, Community-Acquired Infections microbiology, Female, Global Health, Hospitalization, Humans, Immunocompromised Host, Male, Middle Aged, Pneumonia, Bacterial drug therapy, Pneumonia, Bacterial microbiology, Prevalence, Community-Acquired Infections epidemiology, Guideline Adherence, Pneumonia, Bacterial epidemiology, Practice Guidelines as Topic, Practice Patterns, Physicians', Pseudomonas aeruginosa, Streptococcus pneumoniae","Title_Abbreviations":"European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology","Volume":"39"}}
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["Carugati M, Aliberti S, Sotgiu G, Blasi F, Gori A, Menendez R, Encheva M, Gallego M, Leuschner P, Ruiz-Buitrago S, Battaglia S, Fantini R, Pascual-Guardia S, Marin-Corral J, Restrepo MI","GLIMP Collaborators","Publisher: Springer Country of Publication: Germany NLM ID: 8804297 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1435-4373 (Electronic) Linking ISSN: 09349723 NLM ISO Abbreviation: Eur J Clin Microbiol Infect Dis Subsets: MEDLINE","Journal Article; Multicenter Study; Practice Guideline","2020-08-01","European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology [Eur J Clin Microbiol Infect Dis] 2020 Aug; Vol. 39 (8), pp. 1513-1525. Date of Electronic Publication: 2020 Apr 03.","English","1435-4373","Guideline Adherence* , Practice Guidelines as Topic* , Practice Patterns, Physicians'* , Pseudomonas aeruginosa* , Streptococcus pneumoniae*, Community-Acquired Infections\/*epidemiology , Pneumonia, Bacterial\/*epidemiology, Aged ; Aged, 80 and over ; Anti-Bacterial Agents\/therapeutic use ; Community-Acquired Infections\/drug therapy ; Community-Acquired Infections\/microbiology ; Female ; Global Health ; Hospitalization ; Humans ; Immunocompromised Host ; Male ; Middle Aged ; Pneumonia, Bacterial\/drug therapy ; Pneumonia, Bacterial\/microbiology ; Prevalence","Aged, Aged, 80 and over, Anti-Bacterial Agents therapeutic use, Community-Acquired Infections drug therapy, Community-Acquired Infections microbiology, Female, Global Health, Hospitalization, Humans, Immunocompromised Host, Male, Middle Aged, Pneumonia, Bacterial drug therapy, Pneumonia, Bacterial microbiology, Prevalence, Community-Acquired Infections epidemiology, Guideline Adherence, Pneumonia, Bacterial epidemiology, Practice Guidelines as Topic, Practice Patterns, Physicians', Pseudomonas aeruginosa, Streptococcus pneumoniae","European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology","39"]
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