Holbourne's theory that rotational head movement and shear strains were limiting factors in producing acute parenchymal brain damage was a watershed moment in understanding traumatic brain injury (TBI). Long term effects, and in particular neurodegenerative proteinopathy subsequent to TBI, remain theoretical, notwithstanding the poorly understood ‘punch drunk'syndrome of the early and mid-20th century, and the 21st century concept of chronic traumatic encephalopathy. This book, the Handbook of Traumatic Brain Injury and Neurodegeneration, has as its theme the marriage between neurodegenerative disease and neurotrauma through TBI surrogates such as sport, military service, and experimental models, and the legitimacy of that marriage. In the 32 contributions included here, this handbook not only explores the deleterious effects of genuine TBI, but also, and more importantly, the relationship between TBI and neurodegeneration. Controversy notwithstanding, there is much to be learned about the biological effects of TBI, substrates for long-term sequelae, the relationship between TBI and diverse neuropsychiatric disorders, and targets for therapy. The overall message to the neuroscience community from these papers may be a cautionary tale. The null hypothesis, that there is no causal relationship between TBI and progressive neurodegenerative disease, appears to be very much in play, and the book will be of interest to all those working in the field.
Select Content Type
eBooks
Interests
Neurology
Emergency Medicine
Speciality
Emergency Medicine
Neurology
Book Detail
ISSN
9781643680644
Publication Date
Actions
Download in App
Banner image
Cover Image
Event Data
{"title":"Handbook of Traumatic Brain Injury and Neurodegeneration","subtitle":"","e_issn":null,"url":"https:\/\/search.ebscohost.com\/login.aspx?direct=true&db=e600tww&AN=2291581&site=ehost-live&scope=site","series":"Advances in Alzheimer's Disease","edition":"","author":"R.J. Castellani","contract_publisher":"","imprint_publisher":"IOS Press","pub_year":"2020","interest_area":["Neurology"," Emergency Medicine"],"lcc":"RD594","lcsh":"Brain--Wounds and injuries.,Nervous system--Degeneration.","language":"eng","format":"PDF","downloadable":"TRUE","fiction":"FALSE","abridged":"","book_id":"2512583","isbn":"9781643680644","eisbn":"9781643680651","ocn":"1161988400","ddc":"617.481","isPdfLink":false,"isSAML":true,"an":"2291581","number_other":"","type_pub":"","isbn_print":"9789811422713","isbn_electronic":"9789811422720","languages":"English","date_entry":"","date_update":"","doi":"","titleSource":"","date_pub_cy":"","type_document":"","volume":null,"issue":null,"authored_on":"2019-01-01","description":"INTRODUCTION: Hypertension has become a major public health problem in the last few decades. High blood pressure is a serious risk factor for premature cardiovascular disease and end-organ damage including left-ventricular hypertrophy and congestive heart failure, which in turn increases the risk of cardiovascular morbidity and mortality. While studies of hypertension have been performed worldwide in a variety of epidemiological settings such as diabetes, renal function, obesity and thyroid disorders, there is a need to identify appropriate treatment strategies Novel Strategies and Approaches in Hypertension introduces the reader to different aspects of hypertension treatment (environmental and occupational factors and different clinical settings that can trigger the disease). The book also covers special topics related to the use of new diagnostic biomarkers for hypertension patients, as well as endocrine and nutrition-focused approaches to treat the condition. This reference book will be useful for medical professionals involved in the management and care of patients affected with hypertension. [Series Introduction] Frontiers in Hypertension presents reference works, textbooks and monographs on both fundamental and advanced topics related to the pathophysiology, diagnosis and treatment of hypertension. The series is essential reading for medical students and professionals involved in hypertension and allied subspecialty treatment programs.","publication_date":"2019-01-01","upload_link":"https:\/\/search.ebscohost.com\/login.aspx?direct=true&site=eds-live&db=nlebk&AN=2512583&authtype=shib&custid=ns346513&group=main&profile=eds","no_of_pages":"","authored_by":"Hafize Uzun, P\u0131nar Atukeren, Hafize Uzun, P\u0131nar Atukeren","header":{"DbId":"nlebk","DbLabel":"eBook Collection (EBSCOhost)","An":"2512583","RelevancyScore":"1097","PubType":"eBook","PubTypeId":"ebook","PreciseRelevancyScore":"1096.64697265625"},"plink":"https:\/\/search.ebscohost.com\/login.aspx?direct=true&site=eds-live&db=nlebk&AN=2512583&authtype=shib&custid=ns346513&group=main&profile=eds","additionalInfo":{"Authored_By":"R.J. Castellani, R.J. Castellani","Categories":"MEDICAL \/ Neuroscience","Subjects":"Nervous system--Degeneration, Brain--Wounds and injuries","Electronic_ISBN":"9781643680651","Print_ISBN":"9781643680644","Languages":"English","Published_Date":"2020-01-01","Resource_Type":"eBook.","Title_Abbreviations":"Handbook of Traumatic Brain Injury and Neurodegeneration"}}
ISSN
9781643680644
IS_Ebsco
true
Upload Link
https://search.ebscohost.com/login.aspx?direct=true&db=e600tww&AN=2291581&site=ehost-live&scope=site
Additional Info
["R.J. Castellani, R.J. Castellani","MEDICAL \/ Neuroscience","Nervous system--Degeneration, Brain--Wounds and injuries","9781643680651","9781643680644","English","2020-01-01","eBook.","Handbook of Traumatic Brain Injury and Neurodegeneration"]
Description