Historical Perspectives and Guidelines for Botulinum Neurotoxin Subtype Nomenclature.

{"article_title":"Historical Perspectives and Guidelines for Botulinum Neurotoxin Subtype Nomenclature.","author":"Peck MW, Smith TJ, Anniballi F, Austin JW, Bano L, Bradshaw M, Cuervo P, Cheng LW, Derman Y, Dorner BG, Fisher A, Hill KK, Kalb SR, Korkeala H, Lindstr\u00f6m M, Lista F, L\u00faquez C, Mazuet C, Pirazzini M, Popoff MR, Rossetto O, Rummel A, Sesardic D, Singh BR, Stringer SC","journal_title":"Toxins","issn":"2072-6651","isbn":"","publication_date":"2017-01-18","volume":"9","issue":"1","first_page":"","page_count":"","accession_number":"28106761","doi":"","publisher":"MDPI","doctype":"Guideline","subjects":"Botulinum Toxins classification; Terminology as Topic; Botulinum Toxins history; Consensus; History, 20th Century; History, 21st Century; Humans","interest_area":["Neurology"],"abstract":"Botulinum neurotoxins are diverse proteins. They are currently represented by at least seven serotypes and more than 40 subtypes. New clostridial strains that produce novel neurotoxin variants are being identified with increasing frequency, which presents challenges when organizing the nomenclature surrounding these neurotoxins. Worldwide, researchers are faced with the possibility that toxins having identical sequences may be given different designations or novel toxins having unique sequences may be given the same designations on publication. In order to minimize these problems, an ad hoc committee consisting of over 20 researchers in the field of botulinum neurotoxin research was convened to discuss the clarification of the issues involved in botulinum neurotoxin nomenclature. This publication presents a historical overview of the issues and provides guidelines for botulinum neurotoxin subtype nomenclature in the future. Competing Interests: The authors declare no conflict of interest.","url":"https:\/\/search.ebscohost.com\/login.aspx?direct=true&db=mdl&AN=28106761","isPdfLink":true,"isSAML":false,"an":"28106761","number_other":"","type_pub":"","issn_electronic":"2072-6651","languages":"English","language":"eng","date_entry":"","date_update":"","titleSource":"Toxins [Toxins (Basel)] 2017 Jan 18; Vol. 9 (1). Date of Electronic Publication: 2017 Jan 18.","date_pub_cy":"","type_document":"","contract_publisher":"","authored_on":"2017-01-18","description":"Botulinum neurotoxins are diverse proteins. They are currently represented by at least seven serotypes and more than 40 subtypes. New clostridial strains that produce novel neurotoxin variants are being identified with increasing frequency, which presents challenges when organizing the nomenclature surrounding these neurotoxins. Worldwide, researchers are faced with the possibility that toxins having identical sequences may be given different designations or novel toxins having unique sequences may be given the same designations on publication. In order to minimize these problems, an ad hoc committee consisting of over 20 researchers in the field of botulinum neurotoxin research was convened to discuss the clarification of the issues involved in botulinum neurotoxin nomenclature. This publication presents a historical overview of the issues and provides guidelines for botulinum neurotoxin subtype nomenclature in the future.<br \/>Competing Interests: The authors declare no conflict of interest.","upload_link":"https:\/\/search.ebscohost.com\/login.aspx?direct=true&site=eds-live&db=mdl&AN=28106761&authtype=shib&custid=ns346513&group=main&profile=eds","no_of_pages":"","authored_by":"Peck MW, Smith TJ, Anniballi F, Austin JW, Bano L, Bradshaw M, Cuervo P, Cheng LW, Derman Y, Dorner BG, Fisher A, Hill KK, Kalb SR, Korkeala H, Lindstr\u00f6m M, Lista F, L\u00faquez C, Mazuet C, Pirazzini M, Popoff MR, Rossetto O, Rummel A, Sesardic D, Singh BR, Stringer SC","header":{"DbId":"mdl","DbLabel":"MEDLINE Ultimate","An":"28106761","RelevancyScore":"817","PubType":"Academic Journal","PubTypeId":"academicJournal","PreciseRelevancyScore":"816.880981445313"},"plink":"https:\/\/search.ebscohost.com\/login.aspx?direct=true&site=eds-live&db=mdl&AN=28106761&authtype=shib&custid=ns346513&group=main&profile=eds","additionalInfo":{"Authored_By":"Peck MW, Smith TJ, Anniballi F, Austin JW, Bano L, Bradshaw M, Cuervo P, Cheng LW, Derman Y, Dorner BG, Fisher A, Hill KK, Kalb SR, Korkeala H, Lindstr\u00f6m M, Lista F, L\u00faquez C, Mazuet C, Pirazzini M, Popoff MR, Rossetto O, Rummel A, Sesardic D, Singh BR, Stringer SC","Journal_Info":"Publisher: MDPI Country of Publication: Switzerland NLM ID: 101530765 Publication Model: Electronic Cited Medium: Internet ISSN: 2072-6651 (Electronic) Linking ISSN: 20726651 NLM ISO Abbreviation: Toxins (Basel) Subsets: MEDLINE","Publication_Type":"Guideline; Historical Article; Journal Article; Review; Research Support, Non-U.S. Gov't","Published_Date":"2017-01-18","Source":"Toxins [Toxins (Basel)] 2017 Jan 18; Vol. 9 (1). Date of Electronic Publication: 2017 Jan 18.","Languages":"English","Electronic_ISSN":"2072-6651","MeSH_Terms":"Terminology as Topic*, Botulinum Toxins\/*classification, Botulinum Toxins\/history ; Consensus ; History, 20th Century ; History, 21st Century ; Humans","Subjects":"Botulinum Toxins history, Consensus, History, 20th Century, History, 21st Century, Humans, Botulinum Toxins classification, Terminology as Topic","Title_Abbreviations":"Toxins","Volume":"9"}}