Pharmaco-vigilance of oral MethylErgometrine prescriptions for delayed and secondary postpartum haemorrhage.

{"article_title":"Pharmaco-vigilance of oral MethylErgometrine prescriptions for delayed and secondary postpartum haemorrhage.","author":"Pallivalapila AR, Babarinsa IA, Al-Baloushi M, Moursi A, Bayo A, Thomas B, Mahmoud Mohd MG","journal_title":"Journal of perinatal medicine","issn":"1619-3997","isbn":"","publication_date":"2020 Oct 25","volume":"48","issue":"8","first_page":"853","page_count":"","accession_number":"32809964","doi":"10.1515\/jpm-2020-0128","publisher":"Walter De Gruyter","doctype":"Journal Article","subjects":"Qatar; Administration, Oral; Methylergonovine administration & dosage; Methylergonovine adverse effects; Postpartum Hemorrhage diagnosis; Postpartum Hemorrhage drug therapy; Postpartum Hemorrhage etiology; Adult; Female; Health Services Needs and Demand; Humans; Oxytocics administration & dosage; Oxytocics adverse effects; Pharmacovigilance; Postnatal Care methods; Postnatal Care standards; Practice Guidelines as Topic; Practice Patterns, Physicians'; Pregnancy; Qatar epidemiology; Risk Assessment; Safety Management","interest_area":["Obstetrics & Gynecology"," Surgery"," Emergency Medicine"],"abstract":"Objectives The objectives of this study were to quantify the prescription of oral methergin tablets in a busy Women's Hospital, assess the stated indications for such prescription and highlight the issues and safety profile of Methergin use especially in the postpartum patient. Methods Review of prescription data for oral Methergin and the corresponding annual figures on primary and secondary postpartum hemorrhage. Results Over a period of 5 years, oral Methergin prescriptions for delayed and secondary postpartum hemorrhage constituted less than 1% of the overall prescription in Obstetrics and Gynaecology, which ranged between 1214 and 2085 per year. The numbers were too few to ascertain any relationship with both types of postpartum hemorrhage. Although stated on the relevant Patient Information leaflet, no local or regional guideline on its use exist. Conclusions Specific and random trend monitoring of medications for continuing safety profile, risk benefit issues, or unapproved indication, may help in identifying, preventing and mitigating any medication safety matters. Clinical pharmacists in collaboration with physicians are well placed in conducting such pharmacovigilance activities to improve medication safety.","url":"https:\/\/search.ebscohost.com\/login.aspx?direct=true&db=mdl&AN=32809964&authtype=shib&custid=ns346513","isPdfLink":true,"isSAML":false,"additionalInfo":{"Authored_By":"Pallivalapila AR, Babarinsa IA, Al-Baloushi M, Moursi A, Bayo A, Thomas B, Mahmoud Mohd MG","Journal_Info":"Publisher: Walter De Gruyter Country of Publication: Germany NLM ID: 0361031 Publication Model: Print Cited Medium: Internet ISSN: 1619-3997 (Electronic) Linking ISSN: 03005577 NLM ISO Abbreviation: J Perinat Med Subsets: MEDLINE","Publication_Type":"Journal Article","Published_Date":"2020-10-25","Source":"Journal of perinatal medicine [J Perinat Med] 2020 Oct 25; Vol. 48 (8), pp. 853-855.","Languages":"English","Electronic_ISSN":"1619-3997","MeSH_Terms":"Administration, Oral* , Methylergonovine*\/administration & dosage , Methylergonovine*\/adverse effects , Postpartum Hemorrhage*\/diagnosis , Postpartum Hemorrhage*\/drug therapy , Postpartum Hemorrhage*\/etiology, Adult ; Female ; Health Services Needs and Demand ; Humans ; Oxytocics\/administration & dosage ; Oxytocics\/adverse effects ; Pharmacovigilance ; Postnatal Care\/methods ; Postnatal Care\/standards ; Practice Guidelines as Topic ; Practice Patterns, Physicians' ; Pregnancy ; Qatar\/epidemiology ; Risk Assessment ; Safety Management","Subjects":"Adult, Female, Health Services Needs and Demand, Humans, Oxytocics administration & dosage, Oxytocics adverse effects, Pharmacovigilance, Postnatal Care methods, Postnatal Care standards, Practice Guidelines as Topic, Practice Patterns, Physicians', Pregnancy, Qatar epidemiology, Risk Assessment, Safety Management, Administration, Oral, Methylergonovine administration & dosage, Methylergonovine adverse effects, Postpartum Hemorrhage diagnosis, Postpartum Hemorrhage drug therapy, Postpartum Hemorrhage etiology","Title_Abbreviations":"Journal of perinatal medicine","Volume":"48"},"header":{"DbId":"mdl","DbLabel":"MEDLINE Ultimate","An":"32809964","RelevancyScore":"853","PubType":"Academic Journal","PubTypeId":"academicJournal","PreciseRelevancyScore":"852.997863769531"},"plink":"https:\/\/search.ebscohost.com\/login.aspx?direct=true&site=eds-live&db=mdl&AN=32809964&authtype=shib&custid=ns346513&group=main&profile=eds","upload_link":"https:\/\/search.ebscohost.com\/login.aspx?direct=true&site=eds-live&db=mdl&AN=32809964&authtype=shib&custid=ns346513&group=main&profile=eds"}