On the tube.

{"article_title":"[Management guidelines for disorders \/ different sex development (DSD)].","author":"Guerrero-Fern\u00e1ndez J, Azcona San Juli\u00e1n C, Barreiro Conde J, Berm\u00fadez de la Vega JA, Carcavilla Urqu\u00ed A, Casta\u00f1o Gonz\u00e1lez LA, Martos Tello JM, Rodr\u00edguez Est\u00e9vez A, Yeste Fern\u00e1ndez D, Mart\u00ednez Mart\u00ednez L, Mart\u00ednez-Urrutia MJ, Mora Palma C, Aud\u00ed Parera L","journal_title":"Anales de pediatria","issn":"2341-2879","isbn":"","publication_date":"2008-02-09","volume":"197","issue":"2642","first_page":"315.e1-315.e19","page_count":"","accession_number":"30033107","doi":"","publisher":"Elsevier","doctype":"Journal Article","subjects":"Disorders of Sex Development diagnosis; Disorders of Sex Development therapy; Algorithms; Child; Female; Humans; Male","interest_area":["Obstetrics & Gynecology"],"abstract":"Disorders of Sex Development (DSD) include a wide range of anomalies among the chromosomal, gonadal, and phenotypic (genital) characteristics that define sexual differentiation. At present, a definition as Different Sexual Development (DSD) is currently preferred. They originate in the pre-natal stage, are classified according to the sex chromosomes present in the karyotype. The known genetic causes are numerous and heterogeneous, although, in some cases, they may be secondary to maternal factors and\/or exposure to endocrine-disrupting chemicals (EDCs). The diagnosis and treatment of DSD always requires multidisciplinary medical and psychosocial care. An aetiological diagnosis needs the interaction of clinical, biochemical (hormonal), genetic, imaging and, sometimes, surgical examinations. The treatment should deal with sex assignment, the possible need for hormone replacement therapy (adrenal if adrenal function is impaired, and with sex steroids from pubertal age if gonadal function is impaired), as well as the need for surgery on genital structures (currently deferred when possible) and\/or on gonads (depending on the risk of malignancy), the need of psychosocial support and, finally, an adequate organisation of the transition to adult medical specialties. Patient Support Groups have a fundamental role in the support of families, as well as the interaction with professional and social media. The use of Registries and the collaboration between professionals in Working Groups of national and international medical societies are crucial for improving the diagnostic and therapeutic tools required for the care of patients with DSD. Copyright \u00a9 2018 Asociaci\u00f3n Espa\u00f1ola de Pediatr\u00eda. Publicado por Elsevier Espa\u00f1a, S.L.U. All rights reserved.","url":"https:\/\/search.ebscohost.com\/login.aspx?direct=true&db=mdl&AN=30033107","isPdfLink":false,"isSAML":false,"an":"30033107","number_other":"","type_pub":"","issn_electronic":"2341-2879","languages":"English","language":"eng","date_entry":"","date_update":"","titleSource":"New Scientist. 2\/9\/2008, Vol. 197 Issue 2642, p85-85. 1p.","date_pub_cy":"","type_document":"","contract_publisher":"","authored_on":"2008-02-09","description":"A letter to the magazine segment "The Last Word" of "New Scientist" is presented for discussion in a future issue questioning the creation of a particular cloud formation.","upload_link":"https:\/\/search.ebscohost.com\/login.aspx?direct=true&site=eds-live&db=cxh&AN=30033107&authtype=shib&custid=ns346513&group=main&profile=eds","no_of_pages":"","authored_by":"Guerrero-Fern\u00e1ndez J, Azcona San Juli\u00e1n C, Barreiro Conde J, Berm\u00fadez de la Vega JA, Carcavilla Urqu\u00ed A, Casta\u00f1o Gonz\u00e1lez LA, Martos Tello JM, Rodr\u00edguez Est\u00e9vez A, Yeste Fern\u00e1ndez D, Mart\u00ednez Mart\u00ednez L, Mart\u00ednez-Urrutia MJ, Mora Palma C, Aud\u00ed Parera L","header":{"DbId":"cxh","DbLabel":"Biomedical Reference Collection: Corporate","An":"30033107","RelevancyScore":"566","PubType":"Periodical","PubTypeId":"serialPeriodical","PreciseRelevancyScore":"565.905517578125"},"plink":"https:\/\/search.ebscohost.com\/login.aspx?direct=true&site=eds-live&db=cxh&AN=30033107&authtype=shib&custid=ns346513&group=main&profile=eds","issn_print":"02624079","physicalDescription":{"Pagination":{"PageCount":"1","StartPage":"85"}},"additionalInfo":{"Published_Date":"2008-02-09","Source":"New Scientist. 2\/9\/2008, Vol. 197 Issue 2642, p85-85. 1p.","Languages":"English","Subjects":"LETTERS to the editor, CLOUDS","Title_Abbreviations":"New Scientist","Volume":"197"}}