Event Data
{"title":"Clinical Integration: Surgery","subtitle":"","e_issn":null,"url":"https:\/\/search.ebscohost.com\/login.aspx?direct=true&db=e600tww&AN=2932413&site=ehost-live&scope=site","series":"","edition":"","author":"Samuel Chee-Manda Raz-Asiri Arachchi","contract_publisher":"","imprint_publisher":"Scion Publishing","pub_year":"2021","interest_area":["Surgery"],"lcc":"RD31","lcsh":"Surgery.","language":"eng","format":"EPUB,PDF","downloadable":"TRUE","fiction":"FALSE","abridged":"","book_id":"3022651","isbn":"9781911510772","eisbn":"9781911510956","ocn":"1266908523","ddc":"617","isPdfLink":false,"isSAML":true,"an":"2932413","number_other":"","type_pub":"","isbn_print":"9781683461814","isbn_electronic":"9781683461838","languages":"English","date_entry":"","date_update":"","doi":"","titleSource":"","date_pub_cy":"","type_document":"","volume":null,"issue":null,"authored_on":"2020-01-01","description":"Izabela Gatkowska proposes a new SPEECH ASSESSMENT METHOD (SAM), grounded in her clinical experience with dysarthria, awareness of diagnostically important features, and the practical need to confine logopedic examination to tasks diagnostically most important and maximally tolerable by the patient. When diligently applied, the new SAM allows the diagnostician to identify overlapping dysarthric symptoms in greater detail and, when repeated, analyze their dynamics over time. The point of departure for the current study is an analysis of the speech impairments observed in Polish adult neurological patients. Rooted in language, developed and tested in a neurological clinic, this original method of diagnosing dysarthric speech disorders shall be applicable for linguists, psychologists, and clinicians who work with patients speaking Polish, English, or Spanish. Dysarthria, after all, is a neurodegeneratively-conditioned speech disorder whose diagnosis is independent of the patient's mother tongue. This particular volume will be of interest to diagnosticians, clinical speech pathologists, linguists, and all those who need to know (1) how damage to the nervous system influences the entire speech mechanism of adults, thus impairing their oral communication, and \u2012 more importantly \u2012 (2) how acute awareness of speech changes may help pinpoint the specific type of speech disorder and contribute to an earlier diagnosis of a neurodegenerative disease.","publication_date":"2020-01-01","upload_link":"https:\/\/dx.doi.org\/doi:10.1016\/0003-9861%2886%2990756-3","no_of_pages":"","authored_by":"Izabela Gatkowska, Izabela Gatkowska","header":{"DbId":"mdl","DbLabel":"MEDLINE Ultimate","An":"3022651","RelevancyScore":"629","PubType":"Academic Journal","PubTypeId":"academicJournal","PreciseRelevancyScore":"628.93701171875"},"plink":"https:\/\/search.ebscohost.com\/login.aspx?direct=true&site=eds-live&db=mdl&AN=3022651&authtype=shib&custid=ns346513&group=main&profile=eds","additionalInfo":{"Authored_By":"Guha SK, Rose ZB","Subjects":"Animals, Brain metabolism, Enzyme Activation, In Vitro Techniques, Mice, Phosphofructokinase-1 metabolism, Phosphotransferases metabolism, Substrate Specificity, Pentosephosphates biosynthesis","Languages":"English","Published_Date":"1986-11-01","Title_Abbreviations":"Archives of biochemistry and biophysics","Volume":"250"}}
Additional Info
["Guha SK, Rose ZB","Animals, Brain metabolism, Enzyme Activation, In Vitro Techniques, Mice, Phosphofructokinase-1 metabolism, Phosphotransferases metabolism, Substrate Specificity, Pentosephosphates biosynthesis","English","1986-11-01","Archives of biochemistry and biophysics","250"]
Description
Ribose-1,5-bisphosphate is synthesized in a reaction that uses ribose-1(or 5)-P as the phosphoryl acceptor and the acyl-P of 3-phosphoglyceryl phosphate as the donor. Glucose-1,6-bisphosphate is synthesized in a similar reaction. The relative activity with the two substrates remains unchanged over almost 300-fold purification of the enzyme, indicating that glucose-1,6-bisphosphate synthase catalyzes both reactions. The relative V/Km values for alternative phosphoryl acceptors are ribose-1-P (1); glucose-1-P (0.30); mannose-1-P and ribose-5-P (0.11); glucose-6-P (0.10); 2-deoxyglucose-6-P (0.03); and 2-deoxyribose-5-P (0.02). Fructose-1- and 6-phosphates are not substrates. The synthesis of both ribose-1,5-bisphosphate and glucose-1,6-bisphosphate is inhibited by physiologically significant levels of fructose-1,6-bisphosphate, glycerate-2,3-bisphosphate, glycerate-3-phosphate, citrate, and inorganic phosphate. Ribose-1,5-bisphosphate is a strong activator of brain phosphofructokinase.
